卡介苗在体外使新鲜的移行癌细胞和T24细胞系对非主要组织相容性复合体（MHC）限制的细胞毒性敏感。
Bacillus Calmette-Guérin sensitises fresh transitional carcinoma cells and T24 cell line to non-MHC-restricted cytotoxicity in vitro.
作者信息
Kaasinen E S, Kalliomäki P H, Alfthan O S, Timonen T T
机构信息
Department of Surgery, Municipal Hospital, Hyvinkää, Finland.
出版信息
Br J Urol. 1993 Dec;72(6):897-906. doi: 10.1111/j.1464-410x.1993.tb16293.x.
The activity of lymphokine (interleukin-2) activated killer (LAK) cells from 9 patients with transitional cell carcinoma (TCC) was tested against autologous, freshly purified transitional carcinoma cells. Cytotoxicity was relatively low. Bacillus Calmette-Guérin (BCG) substantially augmented both LAK activity and the cytolytic activity of non-stimulated peripheral blood mononuclear cells (PBMC) against autologous TCC when tested with 6 additional TCC patients. A similar enhancing effect of BCG was noted with leucocytes obtained from normal donors when tested against an allogenic T24 cell line. Both natural killer (NK) cells and T cells appeared to be responsible for the increased cytolytic activity caused by BCG. No cytolytic activity was noted against normal transitional epithelial cells. Sensitisation of TCC cells to the immune system may explain the clinical effects of BCG.
对9例移行细胞癌（TCC）患者的淋巴因子（白细胞介素-2）激活的杀伤（LAK）细胞针对自体新鲜纯化的移行癌细胞的活性进行了检测。细胞毒性相对较低。在用另外6例TCC患者进行检测时，卡介苗（BCG）显著增强了LAK活性以及未刺激的外周血单个核细胞（PBMC）对自体TCC的细胞溶解活性。当用来自正常供体的白细胞针对同种异体T24细胞系进行检测时，也观察到了卡介苗类似的增强作用。自然杀伤（NK）细胞和T细胞似乎都对卡介苗引起的细胞溶解活性增加负责。未观察到对正常移行上皮细胞的细胞溶解活性。TCC细胞对免疫系统的致敏作用可能解释了卡介苗的临床效果。
Zotero 插件