裂殖酵母对秋水仙酰胺的敏感性：抗性突变体的通透性和解毒特性
Colcemid sensitivity of fission yeast: permeability and detoxification properties of resistant mutants.
作者信息
Lederberg S, Gourse R L, Sackett D L
出版信息
J Bacteriol. 1977 Jan;129(1):198-201. doi: 10.1128/jb.129.1.198-201.1977.
Abstract
Mutants of Schizosaccharomyces pombe, which were resistant to concentrations of colcemid inhibitory to the wild-type parent, were not diminished in their permeability to colcemid or colchicine. They also did not modify colcemid to a detectable derivative or to a product that was incapable of binding to brain tubulin. The resistance of these mutants was therefore via mechanisms different from those of permeability and detoxification known for animal cells.
摘要
粟酒裂殖酵母的突变体对秋水仙酰胺浓度具有抗性，而该浓度对野生型亲本具有抑制作用，这些突变体对秋水仙酰胺或秋水仙素的通透性并未降低。它们也没有将秋水仙酰胺修饰成可检测到的衍生物或无法与脑微管蛋白结合的产物。因此，这些突变体的抗性是通过与动物细胞已知的通透性和解毒机制不同的机制产生的。
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