慢性肉芽肿病（CGD）患者的抗原呈递细胞对抗破伤风毒素进行加工并呈递给人特异性T细胞克隆的过程未受损害。
Processing and presentation of tetanus toxin by antigen-presenting cells from patients with chronic granulomatous disease (CGD) to human specific T cell clones are not impaired.
作者信息
Barbey C, Tiercy J M, Fairweather N, Niemann H, Seger R, Corradin G
机构信息
Institut de Biochimie, Université de Lausanne, Epalinges, Switzerland.
出版信息
Clin Exp Immunol. 1994 Feb;95(2):227-31. doi: 10.1111/j.1365-2249.1994.tb06515.x.
The capacity of peripheral blood lymphocytes (PBL) or Epstein-Barr virus (EBV)-transformed B cell lines from CGD patients to process and present tetanus toxin (tt)-specific epitopes was assessed using various tt preparations and human tt-specific T cell clones. PBL from all of the donors were able to process and present either native tt and/or denatured tt to human T cell clones specific for various tt epitopes. Furthermore, no difference was found in the antigen requirement when normal or CGD EBV-B cell lines were used as antigen-presenting cells (APC). These results suggest that the deficiency in oxygen metabolism in CGD cells does not affect tt processing and presentation.
利用各种破伤风毒素（tt）制剂和人破伤风毒素特异性T细胞克隆，评估了慢性肉芽肿病（CGD）患者外周血淋巴细胞（PBL）或爱泼斯坦-巴尔病毒（EBV）转化的B细胞系处理和呈递破伤风毒素（tt）特异性表位的能力。所有供体的PBL都能够处理天然tt和/或变性tt，并将其呈递给针对各种tt表位的人T细胞克隆。此外，当使用正常或CGD EBV - B细胞系作为抗原呈递细胞（APC）时，在抗原需求方面未发现差异。这些结果表明，CGD细胞中氧代谢的缺陷并不影响tt的处理和呈递。
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