Okuda Y, Hashimoto A, Yamaguchi T, Fukushi H, Mori S, Tani M, Hirai K, Carmichael L
Department of Veterinary Microbiology, Faculty of Agriculture Gifu University, Japan.
Cornell Vet. 1993 Oct;83(4):291-302.
To examine the possibility of repeated reactivation of canine herpesvirus (CHV), 2 serial treatments with the corticosteroid drug prednisolone (PD) were given at different periods following oral-nasal infection of pups and adult dogs. CHV was not recovered from infected, untreated dogs or from uninfected, treated controls. Viral reactivation of CHV, without clinical signs, was induced twice in 2/3 adults and in 2/3 pups treated at intervals that ranged from 1 to 3 months following the initial infections. Highest viral titers were obtained from nasal swab samples, with lower titers found in the oral pharynx, penis or vagina. In some, but not all dogs, the infectivity titers of the nasal secretion samples were higher after the initial prednisolone treatments than after the second treatments. The duration of viral shedding after the second series of steroid treatments also was shorter than the shedding period following the initial reactivations. The results presented here suggest that latent CHV occurs in both pups and adults dogs following infection and that active infections, with viral shedding, may occur repeatedly for prolonged, but undetermined, periods.
为了研究犬疱疹病毒（CHV）反复激活的可能性，在幼犬和成年犬经口鼻感染后的不同时期，对其进行了两轮皮质类固醇药物泼尼松龙（PD）治疗。在未治疗的感染犬或未感染的治疗对照组中均未检测到CHV。在初次感染后1至3个月的不同间隔期接受治疗的2/3成年犬和2/3幼犬中，两次诱导出了无临床症状的CHV病毒激活。鼻拭子样本中的病毒滴度最高，在口咽部、阴茎或阴道中的滴度较低。在部分而非所有犬只中，初次泼尼松龙治疗后鼻分泌物样本的感染性滴度高于第二次治疗后。第二轮类固醇治疗后的病毒排毒持续时间也短于初次激活后的排毒期。此处呈现的结果表明，幼犬和成年犬感染CHV后均会发生潜伏感染，并且在延长但不确定的时期内，可能会反复出现伴有病毒排出的活跃感染。
