Neumann E
Acta Derm Venereol. 1978;58(6):481-6.
Damaged epidermal cells present in psoriatic lesions were investigated using histochemical and histomorphological methods including ultrathick sections. In early lesions these cells were found throughout the epidermis, being particularly numerous in the upper part of the latter and around the adnexa. In a later developmental stage the damage to the keratinocytes in the suprapapillary region was found to precede the damage to the basement membrane. These findings, together with the difference between the damaged keratinocytes lining the ascending side and the venous limb of the papilla respectively with regard to degree of severity of the damage, suggest that blood stasis is the cause of the regressive changes in the suprapapillary epidermis. The enzymatic activity of non-specific esterases and acid phosphatases was increased and that of succindehydrogenases and DPN-diaphorase was decreased in damage keratinocytes. The significance of these findings in relation to the genesis and development of psoriasis is discussed. The view is expressed that there is a causal relationship between damage to the epidermal cells and proliferation of epidermis.
利用包括超厚切片在内的组织化学和组织形态学方法，对银屑病皮损中受损的表皮细胞进行了研究。在早期皮损中，这些细胞见于整个表皮，在上部及附件周围尤为多见。在疾病发展的后期，发现乳头上方区域角质形成细胞的损伤先于基底膜的损伤。这些发现，以及分别位于乳头上升侧和静脉支的受损角质形成细胞在损伤严重程度上的差异，提示血瘀是乳头上方表皮退行性变化的原因。在受损的角质形成细胞中，非特异性酯酶和酸性磷酸酶的酶活性增加，而琥珀酸脱氢酶和二磷酸吡啶核苷酸黄递酶的酶活性降低。讨论了这些发现与银屑病发生发展的关系。有人认为表皮细胞损伤与表皮增殖之间存在因果关系。
