Odenholt-Tornqvist I, Bengtsson S
Department of Infectious Diseases, University Hospital, Uppsala, Sweden.
Chemotherapy. 1994 Jan-Feb;40(1):30-6. doi: 10.1159/000239167.
The postantibiotic effect (PAE), the postantibiotic sub-MIC effect (PA SME), and the sub-MIC effect (SME) of a new oral quinolone, sparfloxacin, were determined for different strains of gram-negative bacteria. A PAE was induced by 10 x MIC of sparfloxacin for 2 h and the antibiotic was then eliminated by washing and dilution. The PA SME was studied by adding different sub-MICs during the postantibiotic phase, and the SME by exposing the controls to the sub-MICs alone. Growth curves were followed for 20 h by continuous monitoring of optical density in an automatic incubator. Sparfloxacin induced a PAE of 0.9-2.4 h for all strains except two clinical strains of Enterobacter cloacae. In accordance with earlier experiments with sparfloxacin and gram-positive bacteria, this study showed a PA SME that was nearly equal to the PAE plus the effect of the subinhibitory concentration alone (SME).
针对不同的革兰氏阴性菌菌株，测定了新型口服喹诺酮类药物司帕沙星的抗生素后效应（PAE）、抗生素后亚抑菌浓度效应（PA SME）和亚抑菌浓度效应（SME）。通过用10倍MIC的司帕沙星作用2小时诱导产生PAE，然后通过洗涤和稀释去除抗生素。通过在抗生素后阶段添加不同的亚抑菌浓度来研究PA SME，通过将对照单独暴露于亚抑菌浓度来研究SME。在自动培养箱中通过连续监测光密度跟踪生长曲线20小时。除了两株阴沟肠杆菌临床菌株外，司帕沙星对所有菌株诱导产生的PAE为0.9 - 2.4小时。与早期关于司帕沙星和革兰氏阳性菌的实验一致，本研究显示PA SME几乎等于PAE加上单独亚抑菌浓度的效应（SME）。
