食用蜗牛凝集素组织化学表达在晚期结直肠癌中的预后价值。单因素和多因素分析。
Prognostic value of the histochemical expression of helix pomatia agglutinin in advanced colorectal cancer. A univariate and multivariate analysis.
作者信息
Ikeda Y, Mori M, Adachi Y, Matsushima T, Sugimachi K
机构信息
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
出版信息
Dis Colon Rectum. 1994 Feb;37(2):181-4. doi: 10.1007/BF02047545.
PURPOSE
The expression of helix pomatia agglutinin in advanced colorectal cancer was evaluated in order to determine whether helix pomatia agglutinin could serve as an effective prognostic indicator.
METHODS
Using the histochemical procedure, the expression of helix pomatia agglutinin was studied in 117 patients with primary colorectal cancer. Sixty of 117 patients who died of either recurrence or metastasis within two years (Group 1) after resection were compared with the other 57 patients who survived for five years or longer (Group 2).
RESULTS
The helix pomatia agglutinin-positive expression was seen in 34 cases of Group 1 and in only 15 cases of Group 2 (P < 0.01). Lymph node metastasis, lymphatic invasion, venous invasion, mucin production, and helix pomatia agglutinin expression all had a significant correlation with the prognosis in the univariate analysis; however, only lymph node metastasis, venous invasion, and helix pomatia agglutinin expression were prognostic factors with a significant difference in the multivariate analysis.
CONCLUSIONS
Histochemical expression of helix pomatia agglutinin will indeed aid in accurately predicting the prognosis of patients with advanced colorectal cancer.
目的
评估锥螺凝集素在晚期结直肠癌中的表达情况，以确定锥螺凝集素是否可作为有效的预后指标。
方法
采用组织化学方法，对117例原发性结直肠癌患者的锥螺凝集素表达进行研究。将117例患者中术后两年内死于复发或转移的60例患者（第1组）与另外57例存活5年或更长时间的患者（第2组）进行比较。
结果
第1组34例出现锥螺凝集素阳性表达，第2组仅15例出现阳性表达（P<0.01）。单因素分析中，淋巴结转移、淋巴管浸润、静脉浸润、黏液产生及锥螺凝集素表达均与预后显著相关；然而，多因素分析中，只有淋巴结转移、静脉浸润及锥螺凝集素表达是具有显著差异的预后因素。
结论
锥螺凝集素的组织化学表达确实有助于准确预测晚期结直肠癌患者的预后。
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