[Lectin-induced aggregation of neutrophilic granulocytes before and after irradiation of the blood with a helium-neon laser].

To clarify the changes in cellular reactivity in response to single irradiation of blood with He-Ne laser, the authors studied neutrophil aggregation and neutrophil ATP release induced by stimulation with lectins diverse in carbohydrate specificity. Blood samples from 30 healthy donors were investigated using PICA lumoaggregometer (Chrono-Log Corporation, USA) and concanavalin A, PHA-L, WGA, SBA as aggregation inductors. He-Ne laser radiation in most cases results in reduced neutrophil capacity for aggregation. Nevertheless, it activates ATP release under stimulation with lectins of various carbohydrate specificity. It follows that mechanisms of lectin-induced reactions, aggregation of neutrophils and ATP release, are different.