Olovnikova N I, Deriugina E I
Gematol Transfuziol. 1993 Jul-Aug;38(7):3-8.
The authors review current data on the production and characterization of anti-D monoclonal antibodies. The main methods for establishment of anti-D antibody secreting cell lines are considered: EBV-transformation of B lymphocytes from immune donor and hybridization with malignant human or murine cell lines. Serologic and immunological properties of anti-D monoclonal reagents for blood group Rh-typing as well as feasibility of using anti-D monoclonal antibodies as a modality against hemolytic disease of the newborn are discussed.
作者回顾了关于抗-D单克隆抗体的产生及特性的当前数据。文中考虑了建立抗-D抗体分泌细胞系的主要方法：来自免疫供体的B淋巴细胞的EB病毒转化以及与恶性人类或鼠类细胞系的杂交。讨论了用于血型Rh分型的抗-D单克隆试剂的血清学和免疫学特性，以及使用抗-D单克隆抗体作为对抗新生儿溶血病手段的可行性。
