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[药物固定化对其致突变性的修饰。安乃近在淀粉中固定化对小鼠的影响]

[Modification of the mutagenicity of drugs by their immobilization. Effect of immobilization of analgin in starch in mice].

作者信息

Mikheev V S, Togo E F, Pol'kina S I

出版信息

Genetika. 1993 Nov;29(11):1933-5.

PMID:8307381
Abstract

The mutagenic effect of analgin was studied in germ and somatic cells of male mice Mus musculus. It was found that injection of analgin (20 and 40 mg per mouse) significantly increased the frequency of sperm head anomalies and chromosome aberrations in bone marrow cells. Immobilization of analgin in starch led to decrease in the drug immobilization.

摘要

研究了安乃近对雄性小家鼠生殖细胞和体细胞的致突变作用。发现注射安乃近（每只小鼠20毫克和40毫克）显著增加了精子头部异常的频率以及骨髓细胞中的染色体畸变。将安乃近固定在淀粉中导致药物固定作用降低。

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Genetika. 1993 Nov;29(11):1933-5.
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