微电路耦合成肌细胞中乙酰胆碱受体功能的测量
Measurement of acetylcholine receptor function in microcircuit-coupled myoblasts.
作者信息
Quong J N, Fare T L, Bryant H J, Stenger D A
机构信息
Geo-Centers, Inc., Ft. Washington, MD.
出版信息
IEEE Trans Biomed Eng. 1993 Nov;40(11):1122-6. doi: 10.1109/10.245629.
PMID:8307595
Abstract
An electrophysiological measurement principle for long-term, noninvasive monitoring of the nicotinic acetylcholine receptor (nAChR) function is described. The measurement is based on the ability to record agonist-induced depolarizations of clonal myoblasts that have formed high impedance seals with extracellular microcircuit electrodes. The technique appears promising for several types of assays and environmental monitoring applications.
摘要
本文描述了一种用于长期、无创监测烟碱型乙酰胆碱受体（nAChR）功能的电生理测量原理。该测量基于记录激动剂诱导的与细胞外微电路电极形成高阻抗封接的克隆成肌细胞去极化的能力。这项技术在几种类型的检测和环境监测应用中似乎很有前景。
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