Swanson J A, Kern D F
Department of Physiology, James H. Quillen College of Medicine, Johnson City, Tennessee 37614-0576.
J Appl Physiol (1985). 1993 Nov;75(5):2326-31. doi: 10.1152/jappl.1993.75.5.2326.
The effect of papaverine on the albumin permeability-surface area product (PS), reflection coefficient (sigma), and capillary filtration coefficient (Kf) was examined in isolated rabbit lungs. Because PS and Kf are functions of vascular surface area and permeability, we also compared papaverine with two other means of maximizing lung surface area: isoproterenol (1 x 10(-7) M) and a mild increase in vascular pressure. Only lungs perfused with 0.1 mg/ml papaverine were significantly different from control. PS increased from control (2.80 +/- 0.16 to 5.53 +/- 0.20 ml.min-1.g dry lung-1 x 10(-2), whereas sigma decreased from control (0.92 +/- 0.01 to 0.78 +/- 0.03). Kf after papaverine was significantly lower than baseline predrug Kf (5.60 +/- 0.78 to 4.56 +/- 0.53 ml.s-1.cmH2O-1.g dry lung-1 x 10(-3). However, this group's predrug Kf was higher than that of any other group. Our results indicate that papaverine increases albumin permeability and decreases endothelial selectivity. The isolated perfused lung appears fully recruited, because Kf and PS did not increase with isoproterenol or increased vascular pressure. Papaverine should be used with caution in the Ringer-perfused lung.
在离体兔肺中研究了罂粟碱对白蛋白通透率-表面积乘积（PS）、反射系数（σ）和毛细血管滤过系数（Kf）的影响。由于PS和Kf是血管表面积和通透性的函数，我们还将罂粟碱与另外两种使肺表面积最大化的方法进行了比较：异丙肾上腺素（1×10⁻⁷ M）和轻度升高血管压力。只有用0.1 mg/ml罂粟碱灌注的肺与对照组有显著差异。PS从对照组的（2.80±0.16增至5.53±0.20 ml·min⁻¹·g干肺⁻¹×10⁻²），而σ从对照组的（0.92±0.01降至0.78±0.03）。罂粟碱处理后的Kf显著低于给药前的基线Kf（5.60±0.78降至4.56±0.53 ml·s⁻¹·cmH₂O⁻¹·g干肺⁻¹×10⁻³）。然而，该组给药前的Kf高于其他任何组。我们的结果表明，罂粟碱增加白蛋白通透性并降低内皮选择性。离体灌注肺似乎已完全开放，因为Kf和PS并未因异丙肾上腺素或血管压力升高而增加。在林格液灌注的肺中使用罂粟碱时应谨慎。
