Pastorello E A, Riario-Sforza G G, Incorvaia C, Segala M, Fumagalli M, Gandini R
First Department of Internal Medicine, University of Milan, Italy.
J Allergy Clin Immunol. 1994 Jan;93(1 Pt 1):85-92. doi: 10.1016/0091-6749(94)90236-4.
Inspiratory nasal resistance, symptom score, and influx of inflammatory cells into the nose were evaluated before and after a nasal challenge in 15 patients with grass pollen rhinitis and in six nonallergic control subjects, to study the nasal late-phase reaction and its relationship with nasal cytology. All patients had an immediate positive reaction to specific nasal challenge. In seven allergic subjects we observed a later inspiratory nasal resistance increase, but only two had a significant late symptom score. Inflammatory cells increased by 8 hours in all the patients; the higher the cell influx, the higher the symptom score. Close correlations were found between the inspiratory nasal resistance increase, nasal obstruction at hours 8 and 24, and all cell counts. In control challenges there were no significant increases of symptom score or inspiratory nasal resistance either during the challenge or in the next 24 hours. A weakly significant increase was found only for neutrophil counts at 8 hours. These results indicate that an inflammatory reaction constantly occurs after a specific nasal challenge; its extent is closely related to inspiratory nasal resistance and to the intensity of nasal obstruction. Moreover, our data outline the pivotal role played by eosinophils and basophils in the genesis of an allergic late-phase reaction in the nose.
对15例草花粉性鼻炎患者和6例非过敏性对照受试者在鼻腔激发前后进行吸气性鼻阻力、症状评分及炎性细胞向鼻腔内流入情况的评估，以研究鼻迟发相反应及其与鼻细胞学的关系。所有患者对特异性鼻腔激发均有即刻阳性反应。在7例变应性受试者中，我们观察到后期吸气性鼻阻力增加，但仅有2例有显著的迟发症状评分。所有患者的炎性细胞在8小时时增加；细胞流入量越高，症状评分越高。在吸气性鼻阻力增加、8小时和24小时时的鼻阻塞与所有细胞计数之间发现密切相关性。在对照激发中，无论是激发期间还是接下来的24小时内，症状评分或吸气性鼻阻力均无显著增加。仅在8小时时发现中性粒细胞计数有微弱的显著增加。这些结果表明，特异性鼻腔激发后持续发生炎性反应；其程度与吸气性鼻阻力及鼻阻塞强度密切相关。此外，我们的数据概述了嗜酸性粒细胞和嗜碱性粒细胞在鼻部变应性迟发相反应发生过程中所起的关键作用。
