Hoffman E J, Phelps M E, Weiss E S, Welch M J, Coleman R E, Sobel B E, Ter-Pogossian M M
J Nucl Med. 1977 Jan;18(1):57-61.
Radiopharmaceuticals incorporated directly into the metabolic pathways in myocardium provide a useful means for evaluating such processes. Palmitic acid, a major physiologic substrate of myocardium, has a well-understood role in myocardial metabolism. Accordingly, 11C-palmitic acid was the substrate chosen for use in conjunction with positron emission transaxial tomography to obtain images of canine myocardium. This procedure provides high-contrast images of tranverse sections of the myocardium, with good target-to-nontarget ratios (in the image), over a period of 5 to 85 minutes. Clearance half-times for blood and myocardial tissue were found to be 4.8 and 330 min, respectively. In normal myocardium, images obtained with 11C-palmitic acid were those obtained with 13NH3 and 11CO-hemoglobin. In vivo images of hearts with myocardial infarcts showed a clear delineration of infarcts and normal tissue.
直接纳入心肌代谢途径的放射性药物为评估此类过程提供了一种有用的手段。棕榈酸是心肌的主要生理底物，在心肌代谢中具有明确的作用。因此，11C-棕榈酸被选为与正电子发射断层扫描结合使用的底物，以获取犬心肌的图像。该程序在5至85分钟的时间内提供心肌横切面的高对比度图像，（图像中）靶与非靶比率良好。发现血液和心肌组织的清除半衰期分别为4.8分钟和330分钟。在正常心肌中，用11C-棕榈酸获得的图像与用13NH3和11CO-血红蛋白获得的图像相同。患有心肌梗死的心脏的体内图像显示梗死区和正常组织有明显的分界。
