Imawaki S, Maeta H, Shiraishi Y, Arioka I, Ugawa T, Tanaka S
First Department of Surgery, Kagawa Medical School, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1994 Jan;42(1):31-7.
Autotransfusion of the shed mediastinal blood after cardiac operations was performed in 20 cases (ATS group). Safety and efficacy of the autotransfusion were studied comparing with the 10 cases without autotransfusion (control group). A 65.1 +/- 17.1% of bleeding volume within 24 hours after surgery was autotransfused in the ATS group. The ATS group received 1,396 +/- 1,674 ml of the banked blood compared with 780 +/- 1,194 ml for the control group. There was no significant difference between two groups in regard to saving the banked blood. Hematological and biochemical studies after surgery in the ATS and control groups revealed that CPK, BUN and creatinine of the ATS group were significantly higher than those of the control group, although these changes were transitory and trivial. However, prothrombin time of the ATS group was lower than that of control group, so there may be the possibility that this technique itself increases the hemorrhage. Since the cardiotomy filter was obstructed with clots in cases of massive bleeding, shed mediastinal blood may not be fully defibrinogenated in the cases with massive bleeding. These results lead to the following conclusions: autotransfusion of the shed mediastinal blood after cardiac operations is a safe method, but the efficacy of it is doubtful.
对20例心脏手术后纵隔引流血进行自体输血(自体输血组)。与10例未进行自体输血的患者(对照组)比较,研究自体输血的安全性和有效性。自体输血组术后24小时内65.1±17.1%的出血量被自体回输。自体输血组输注库存血1396±1674ml,而对照组为780±1194ml。两组在节省库存血方面无显著差异。自体输血组和对照组术后血液学和生化研究显示,尽管这些变化是暂时的且轻微的,但自体输血组的肌酸磷酸激酶、尿素氮和肌酐显著高于对照组。然而,自体输血组的凝血酶原时间低于对照组,因此该技术本身可能增加出血风险。由于在大出血病例中,心内直视手术滤器被血栓阻塞,大出血病例中纵隔引流血可能未完全去纤维蛋白原。这些结果得出以下结论:心脏手术后纵隔引流血自体输血是一种安全的方法,但其有效性值得怀疑。