Kitagawa Y
Department of Orthopaedic Surgery, Nippon Medical School, Tokyo, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1993 Dec;67(12):1140-50.
A comparative study concerning the histogenesis of Ewing's sarcoma and its relationship with peripheral primitive neuroectodermal tumor (PNET) was undertaken using histological, immunohistochemical and ultrastructural techniques. The cases studied included 22 Ewing's sarcomas, 17 (ganglio) neuroblastomas, 3 peripheral PNETs, 1 peripheral neuroblastoma, 1 Askin's tumor and a case in which it was difficult to distinguish between Ewing's sarcoma and neuroblastoma. Almost all the cases of Ewing's sarcoma showed neural differentiations. Immunohistochemical study using antibodies for neuron-specific enolase, protein gene product 9.5, Leu 7 and neurofilament (200 kD) was most useful for examining the neural differentiation of these tumors. These results suggest that Ewing's sarcoma is in a broad sense one of such peripheral PNETs as (ganglio) neuroblastoma, peripheral neuroblastoma and Askin's tumor.
采用组织学、免疫组织化学和超微结构技术，对尤因肉瘤的组织发生及其与外周原始神经外胚层肿瘤（PNET）的关系进行了一项比较研究。所研究的病例包括22例尤因肉瘤、17例（神经节）神经母细胞瘤、3例外周PNET、1例外周神经母细胞瘤、1例阿金氏瘤以及1例难以区分尤因肉瘤和神经母细胞瘤的病例。几乎所有尤因肉瘤病例均显示神经分化。使用针对神经元特异性烯醇化酶、蛋白基因产物9.5、Leu 7和神经丝（200 kD）的抗体进行免疫组织化学研究，对检查这些肿瘤的神经分化最为有用。这些结果表明，从广义上讲，尤因肉瘤是（神经节）神经母细胞瘤、外周神经母细胞瘤和阿金氏瘤等外周PNET之一。
