Gloor J M, Muchant D G, Norling L L
Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908.
J Perinatol. 1993 Nov-Dec;13(6):425-7.
The short-term use of indomethacin has been shown to be relatively safe and effective in halting premature labor. Its use has been associated with adverse renal effects in both the fetal and newborn periods that are generally transient and resolve on discontinuation of the drug. However, limited data suggest that prolonged prenatal exposure to indomethacin may be harmful to the fetus. We report a case of prolonged severe renal dysfunction characterized by oligohydramnios and postnatal anuria, azotemia, and ultrasonographic kidney abnormalities associated with the long-term prenatal use of indomethacin. Although partial resolution was observed, a moderate decrease in renal function persists. Prenatal maternal indomethacin use represents a potential cause of renal dysfunction in the newborn infant that may be only partially reversible.
短期使用吲哚美辛已被证明在阻止早产方面相对安全有效。其使用与胎儿期和新生儿期的不良肾脏影响有关，这些影响通常是短暂的，停药后会消退。然而，有限的数据表明，孕期长期接触吲哚美辛可能对胎儿有害。我们报告一例长期严重肾功能不全的病例，其特征为羊水过少、出生后无尿、氮质血症以及与孕期长期使用吲哚美辛相关的肾脏超声异常。尽管观察到部分缓解，但肾功能仍持续中度下降。产前母亲使用吲哚美辛是新生儿肾功能不全的一个潜在原因，可能只是部分可逆。
