Wurtzel D
Division of Neonatology, Albert Einstein Medical Center, Philadelphia, Pennsylvania.
Obstet Gynecol. 1990 Oct;76(4):689-92.
Renal function was evaluated in premature infants whose mothers received long-term indomethacin for tocolysis. Creatinine, urine and serum osmolalities, fractional excretion of sodium, and glomerular filtration rate were compared during the first 10 postnatal days in 14 preterm infants exposed to indomethacin in utero and in ten control infants. Renal function in both groups was comparable, with no significant differences on any study date in serum urea nitrogen and creatinine, ratio of urine osmolality to serum osmolality, fractional excretion of sodium, or glomerular filtration rate. These data suggest that long-term intrauterine administration of indomethacin does not significantly alter renal function.
对母亲因保胎而长期使用吲哚美辛的早产儿的肾功能进行了评估。比较了14名在子宫内接触过吲哚美辛的早产儿和10名对照婴儿出生后前10天内的肌酐、尿和血清渗透压、钠排泄分数以及肾小球滤过率。两组的肾功能相当，在任何研究日期，血清尿素氮和肌酐、尿渗透压与血清渗透压之比、钠排泄分数或肾小球滤过率均无显著差异。这些数据表明，长期宫内给予吲哚美辛不会显著改变肾功能。
