Kameda H, Kuwana M, Hama N, Kaburaki J, Homma M
Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
J Rheumatol. 1997 Feb;24(2):400-3.
We describe 3 Japanese patients having both serum anti-DNA topoisomerase I and anti-Sm antibodies. All 3 patients had typical features of systemic lupus erythematosus, such as glomerulonephritis, in addition to skin thickening and systemic sclerosis related organ involvement, including pulmonary interstitial fibrosis and renal crisis. This is the first report of the coexistence of these 2 disease specific autoantibodies.
我们描述了3例同时具有血清抗DNA拓扑异构酶I抗体和抗Sm抗体的日本患者。所有3例患者除了有皮肤增厚和系统性硬化相关器官受累（包括肺间质纤维化和肾危象）外，还具有系统性红斑狼疮的典型特征，如肾小球肾炎。这是这两种疾病特异性自身抗体共存的首次报告。
