在可卡因和苯环利定戒断过程中对丁螺环酮的行为反应。

Behavioral response to buspirone in cocaine and phencyclidine withdrawal.

作者信息

Giannini A J, Loiselle R H, Graham B H, Folts D J

机构信息

Department of Psychiatry, Ohio State University, Columbus.

出版信息

J Subst Abuse Treat. 1993 Nov-Dec;10(6):523-7. doi: 10.1016/0740-5472(93)90055-7.

DOI:10.1016/0740-5472(93)90055-7

PMID:8308936

Abstract

The effects of buspirone in treating cocaine and phencyclidine (PCP) withdrawal were studied. Withdrawal symptoms of these two street-drugs are thought to be due to norepinephrine, dopamine and possibly serotonin depletion. Buspirone acts by enhancing dopaminergic and noradrenergic firing as well by suppressing serotonergic activity. Thirty-two cocaine abusers and 24 PCP abusers were withdrawn over a 30-day period. Half of each group received buspirone 10 mg t.i.d. and the other half 10 mg placebo t.i.d. In the cocaine group, buspirone was significantly more effective from the fifth day onward. In the PCP group, significant improvement was seen on the thirtieth day. Delayed effectiveness in PCP is thought due to its actions at other neurotransmitter sites.

摘要

研究了丁螺环酮治疗可卡因和苯环己哌啶（PCP）戒断的效果。这两种街头毒品的戒断症状被认为是由于去甲肾上腺素、多巴胺以及可能的血清素耗竭所致。丁螺环酮通过增强多巴胺能和去甲肾上腺素能放电以及抑制血清素能活性发挥作用。32名可卡因滥用者和24名PCP滥用者在30天内进行了戒断。每组一半的人每日三次服用10毫克丁螺环酮，另一半每日三次服用10毫克安慰剂。在可卡因组中，从第五天起丁螺环酮的效果显著更佳。在PCP组中，在第三十天观察到了显著改善。PCP效果延迟被认为是由于其在其他神经递质位点的作用。