Uchiumi R, Hidaka T, Miyagawa A, Sugino K, Taniguchi K, Honda N
Department of Anesthesiology, Oita Medical University.
Masui. 1994 Jan;43(1):102-5.
Anesthesiologists need a safe and effective premedication before general anesthesia and want to help decrease anxiety and minimize psychologic trauma to children. Therefore, we evaluated diazepam suppository (0.5 mg.kg-1 body weight) administered to 21 children before minor surgery under general anesthesia. We evaluated the sedative effect of the diazepam suppository (tablet) on the arrival at the operating room, during anesthesia induction and in the recovery room. On the arrival at operating room, 86% of children were sedated, and 65% of children could be induced smoothly under mask. There was no delayed emergence. Plasma diazepam level at induction was 376.5 +/- 28.4 ng.ml-1, which is the level needed for sedation. We conclude that diazepam suppository is a useful drug for premedication in children.
麻醉医生在全身麻醉前需要一种安全有效的术前用药，并且希望有助于减轻焦虑并将对儿童的心理创伤降至最低。因此，我们评估了在全身麻醉下对21名儿童进行小手术前给予地西泮栓剂（0.5毫克/千克体重）的情况。我们评估了地西泮栓剂（片剂）在到达手术室时、麻醉诱导期间和恢复室中的镇静效果。到达手术室时，86%的儿童处于镇静状态，65%的儿童可在面罩下顺利诱导。没有延迟苏醒。诱导时血浆地西泮水平为376.5±28.4纳克/毫升，这是镇静所需的水平。我们得出结论，地西泮栓剂是儿童术前用药的一种有用药物。
