Luo X X, Ogata H
1st Department of Anesthesiology, Dokkyo University, School of Medicine, Tochigi.
Masui. 1994 Jan;43(1):70-7.
This study was conducted to investigate the effect of 20% marine salt as compared with 20% NaCl solution, on the circulatory dynamics in hemorrhagic shock using mongrel dogs. Ten mongrel dogs were randomly divided into two groups. One treated with 20% marine salt, and the other treated with 20% NaCl. Modified Wigger's method was used to induce hemorrhagic shock. Hypotension was kept at 45 mmHg for 45 minutes and then 1.5 ml.kg-1 of 20% marine salt or 20% NaCl was injected intravenously in bolus. Twenty percent marine salt reduced total peripheral resistance and increased cardiac output with statistically significant difference compared with 20% NaCl. There were increases in MAP, PAP and PWP without statistic differences between the two groups. These results suggest that 20% marine salt, including various trace elements, is superior to 20% NaCl in improving cardiac output and TPR during hemorrhagic shock.
本研究旨在探讨20%海盐与20%氯化钠溶液相比，对杂种犬失血性休克循环动力学的影响。十只杂种犬被随机分为两组。一组用20%海盐治疗，另一组用20%氯化钠治疗。采用改良的维格氏法诱导失血性休克。将低血压维持在45 mmHg 45分钟，然后静脉推注1.5 ml·kg-1的20%海盐或20%氯化钠。与20%氯化钠相比，20%海盐降低了总外周阻力，增加了心输出量，差异具有统计学意义。两组间平均动脉压、肺动脉压和肺毛细血管楔压均升高，但无统计学差异。这些结果表明，含多种微量元素的20%海盐在改善失血性休克期间的心输出量和总外周阻力方面优于20%氯化钠。
