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[心源性休克。静脉溶栓失败后行冠状动脉血管成形术]

[Cardiogenic shock. Coronary angioplasty after failed intravenous thrombolysis].

作者信息

Krupa H, Pluta W, Kalarus Z, Buszman P, Gasior M, Pasyk S

机构信息

I Katedry i Kliniki Kardiologii Slaskiej Akademii Medycznej, Zabrzu.

出版信息

Kardiol Pol. 1993 Nov;39(11):346-9; discussion 350-7.

PMID:8309166
Abstract

Rescue coronary angioplasty (PTCA) was employed as reperfusion strategy after unsuccessful intracoronary infusion of streptokinase in 13 patients with AMI complicated by cardiogenic shock (CS). Reperfusion defined as reestablishment of TIMI 3 degree flow in the infarct related artery and reduction in luminal narrowing to less than 50% was achieved in 8 patients (61.5%). The failure of PTCA was caused by: inability to cross occlusion in 2 patients and recurrent thrombosis despite repeated dilatations resulting in hemodynamic instability requiring cardiopulmonary resuscitations during the procedure in 3 patients. There was no significant differences in mean age, sex, time from onset of symptoms, LVEF, artery involved, extent of coronary disease and incidence of cardiopulmonary resuscitations during the procedures. There where 4 in-hospital deaths among patients with failed PTCA (80%) compared to 25% mortality in reperfused group. We conclude that PTCA is an effective method of achieving reperfusion in patients with CS complicating AMI after failed thrombolysis with intracoronary streptokinase and that it improves in-hospital survival.

摘要

13例急性心肌梗死(AMI)合并心源性休克(CS)患者,在冠状动脉内输注链激酶未成功后,采用挽救性冠状动脉血管成形术(PTCA)作为再灌注策略。8例患者(61.5%)实现了再灌注,定义为梗死相关动脉恢复TIMI 3级血流且管腔狭窄减少至小于50%。PTCA失败的原因包括:2例患者无法通过闭塞病变,3例患者尽管反复扩张仍发生反复血栓形成,导致术中血流动力学不稳定需要进行心肺复苏。患者的平均年龄、性别、症状发作时间、左心室射血分数、受累动脉、冠状动脉疾病程度及术中心肺复苏发生率无显著差异。PTCA失败的患者中有4例院内死亡(80%),而再灌注组的死亡率为25%。我们得出结论,PTCA是急性心肌梗死合并心源性休克患者在冠状动脉内链激酶溶栓失败后实现再灌注的有效方法,且能提高院内生存率。

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