Kintz P, Mangin P
Institut de Médecine Légale, Strasbourg, France.
J Anal Toxicol. 1993 Nov-Dec;17(7):408-10. doi: 10.1093/jat/17.7.408.
A sensitive and specific quantitative assay for the determination of meprobamate in human fluids and hair is described. Meprobamate and an internal standard, vinylbarbital, are isolated by acid extraction and methylated by derivatization. The final extract is separated on a 12-m capillary column HP-1 and drugs are detected by selected ion monitoring at m/z 162 and m/z 182 for meprobamate and the internal standard, respectively. Applications in forensic science, particularly for hair analysis, are presented.
本文描述了一种用于测定人体体液和毛发中眠尔通的灵敏且特异的定量分析方法。眠尔通和内标物乙烯巴比妥通过酸萃取进行分离，并通过衍生化进行甲基化。最终提取物在12米长的HP-1毛细管柱上进行分离，分别通过选择离子监测在质荷比162和质荷比182处检测眠尔通和内标物的药物。文中介绍了该方法在法医学中的应用，特别是在毛发分析方面的应用。
