SR 48692，一种非肽类神经降压素受体拮抗剂，可阻断神经降压素在豚鼠体内引发的心血管效应。
SR 48692, a non-peptide neurotensin receptor antagonist, blocks the cardiovascular effects elicited by neurotensin in guinea pigs.
作者信息
Nisato D, Guiraudou P, Barthélémy G, Gully D, Le Fur G
机构信息
Sanofi Recherche, Montpellier, France.
出版信息
Life Sci. 1994;54(7):PL95-100. doi: 10.1016/0024-3205(94)00411-0.
PMID:8309346
Abstract
In guinea pigs anaesthetized with sodium pentobarbital, SR 48692, a non peptide neurotensin receptor antagonist blunted the blood pressure increase induced by exogenous neurotensin in a dose dependent manner. Furthermore, in isolated spontaneously beating guinea pig atria, both the tachycardia and inotropic responses induced by neurotensin were potently antagonized. SR 48692 did not show any intrinsic effect in vivo or in vitro.
摘要
在用戊巴比妥钠麻醉的豚鼠中，非肽类神经降压素受体拮抗剂SR 48692能以剂量依赖的方式减弱外源性神经降压素引起的血压升高。此外，在离体自发搏动的豚鼠心房中，神经降压素引起的心动过速和变力反应均被有效拮抗。SR 48692在体内或体外均未表现出任何内在效应。
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