Ringelberg J, van de Bor M
Department of Pediatrics, University Hospital Leiden, The Netherlands.
Neuropediatrics. 1993 Oct;24(5):269-73. doi: 10.1055/s-2008-1071555.
In this prospective study routine ultrasound scanning of the brain was performed in all 353 infants of less than 32 weeks of gestation who had been admitted to our neonatal intensive care unit from 1987-1990. Ten infants (2.8%) showed transient periventricular echodensities (TPE) without the subsequent development of cysts and/or ventricular dilation. Nineteen infants (5.4%) developed periventricular leukomalacia (PVL). At the corrected age of 2 years the neurodevelopmental outcome was assessed. Five children with PVL had died before the age of 2 years. The neurodevelopmental outcome of children with TPE and PVL was compared with the outcome of 21 preterm children matched for gestational age, birth weight and severity of illness, and without ultrasound abnormalities of the brain in the neonatal period, who had also been admitted to our neonatal intensive care unit during the study period. Children with TPE and PVL appeared to have more handicaps than the control children. The children with TPE had significantly more minor motor handicaps than the control children, while the children with PVL had more major handicaps of all origins. Although infants with TPE had a more favorable prognosis than infants with PVL they should not be disregarded because TPE appear to be of clinical importance.
在这项前瞻性研究中，对1987年至1990年间入住我们新生儿重症监护病房的所有353名孕周小于32周的婴儿进行了常规脑部超声扫描。10名婴儿（2.8%）出现短暂性脑室周围回声增强（TPE），随后未出现囊肿和/或脑室扩张。19名婴儿（5.4%）发生了脑室周围白质软化（PVL）。在矫正年龄2岁时评估神经发育结局。5名患有PVL的儿童在2岁前死亡。将患有TPE和PVL的儿童的神经发育结局与21名孕周、出生体重和疾病严重程度相匹配且在新生儿期脑部无超声异常的早产儿童的结局进行了比较，这些早产儿童在研究期间也入住了我们的新生儿重症监护病房。患有TPE和PVL的儿童似乎比对照儿童有更多的缺陷。患有TPE的儿童比对照儿童有明显更多的轻度运动障碍，而患有PVL的儿童有更多各种原因导致的重度障碍。尽管患有TPE的婴儿比患有PVL的婴儿预后更好，但TPE似乎具有临床重要性，不应被忽视。
