Topographical organization of the sources of discrete cortical projections within the striatum as determined by a retrograde fluorescence tracing technique in the cat.

The projections from the neostriatum and the paleostriatum to the cerebral cortex in the cat were examined by means of retrogradely transported fluorescent tracers primuline, Fast Blue, Nuclear Yellow and Evans Blue injected into different neocortical fields. In all cases after dye injections only large labelled cells of sources of striatocortical ipsilateral projections were observed. The main projections from the caudate nucleus and the putamen are directed to the auditory and neighbouring "associative" cortex, and more numerous projections from the globus pallidus are addressed to the motor cortex. No sources of cortical projections within the entopeduncular nucleus were found. Simultaneous injections of Fast Blue and primuline into even closely located and tightly bound functional regions of parietal or temporal cortex failed to reveal double-labelled neurons in the caudate nucleus, internal capsule, putamen and globus pallidus. Thus, our findings on cats are consistent with recent studies on rats and monkeys that suggest that striatal neurons innervate relatively small, restricted fields of the neocortex. Again, the results show evidence for a significant contribution to cholinergic cortical innervation not only of magnocellular neurons of the basal forebrain but also of large neo- and paleostriatal cells.