[上消化道出血。特利加压素与奥曲肽的比较]

[Upper digestive hemorrhage. Comparison of terlipressin and octreotide].

作者信息

Campisi C, Padula P, Peressini A, Boccardo F, Biraghi M, Casaccia M

机构信息

Dipartimento di Chirurgia d'Urgenza, Ospedale S. Martino, Università degli Studi di Genova.

出版信息

Minerva Chir. 1993 Oct 15;48(19):1091-6.

PMID:8309607

Abstract

The efficacy and tolerability of both Terlipressin and Octreotide in the treatment of upper digestive haemorrhage (oesophagus, stomach and duodenum) have been compared, at random, on 30 adult patients. Terlipressin dosage was 2 mg/4 hours i.v. during the first 24 hours, 2 mg/6 hours during the following 24 hours. Octreotide dosage was 50 micrograms i.v. and infusional therapy, 25 micrograms/hours, followed. Haemostasis was obtained in 100% of patients treated with Terlipressin and in 73% of patients treated with Octreotide. Rebleeding occurred in 3 patients treated with Terlipressin and 4 patients treated with Octreotide. Side effects occurred in 4 patients treated with Terlipressin and 8 patients treated with Octreotide. Terlipressin proved to have a better efficacy in comparison with Octreotide, and had less side effects.

摘要

对30例成年患者进行了随机对照研究，比较了特利加压素和奥曲肽治疗上消化道出血（食管、胃和十二指肠）的疗效和耐受性。特利加压素的剂量为：最初24小时静脉注射2毫克/4小时，随后24小时2毫克/6小时。奥曲肽的剂量为静脉注射50微克，随后进行25微克/小时的静脉滴注治疗。接受特利加压素治疗的患者100%实现止血，接受奥曲肽治疗的患者73%实现止血。接受特利加压素治疗的患者中有3例再出血，接受奥曲肽治疗的患者中有4例再出血。接受特利加压素治疗的患者中有4例出现副作用，接受奥曲肽治疗的患者中有8例出现副作用。结果表明，与奥曲肽相比，特利加压素疗效更好，副作用更少。