摄入的短裸甲藻毒素（PbTx-3）在大鼠体内的分布与消除。
Distribution and elimination of ingested brevetoxin (PbTx-3) in rats.
作者信息
Cattet M, Geraci J R
机构信息
Department of Pathology, Ontario Veterinary College, University of Guelph, Canada.
出版信息
Toxicon. 1993 Nov;31(11):1483-6. doi: 10.1016/0041-0101(93)90214-4.
As a first step towards understanding the pathologic effects of ingested brevetoxin (PbTx) in marine mammals, we determined how [3H]PbTx-3 was distributed and eliminated when ingested at sub-lethal dosages (18.6 micrograms/kg) by Fischer 344 rats. Brevetoxin was distributed widely in the body, but concentrated primarily in the liver. It was eliminated in equivalent quantities through the urine and feces. However, we believe urinary clearance is the primary route for PbTx-3 absorbed from the gastrointestinal tract.
作为了解摄入的短裸甲藻毒素（PbTx）对海洋哺乳动物病理影响的第一步，我们测定了费希尔344大鼠以亚致死剂量（18.6微克/千克）摄入[3H]PbTx - 3后，其在体内的分布和消除情况。短裸甲藻毒素在体内广泛分布，但主要集中在肝脏。它通过尿液和粪便以等量排出。然而，我们认为尿液清除是胃肠道吸收的PbTx - 3的主要排泄途径。
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