Cline T W
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Trends Genet. 1993 Nov;9(11):385-90. doi: 10.1016/0168-9525(93)90138-8.
Seventy years after the discovery that sex in Drosophila melanogaster is determined by the balance between X chromosomes and autosomes, we can finally identify some of the specific genes whose relative dosage is responsible for the male/female decision in somatic cells and study how they act at the molecular level. Discovery of these sex determination genes was delayed because their mutant phenotypes were unanticipated. It now seems appropriate to consider how the concept of the X/A balance may have limited thinking about the fruit fly sex determination signal.
在发现黑腹果蝇的性别由X染色体和常染色体之间的平衡决定70年后，我们终于能够鉴定出一些特定基因，其相对剂量决定了体细胞中的雄性/雌性分化，并研究它们在分子水平上的作用方式。这些性别决定基因的发现被推迟了，因为它们的突变表型出乎意料。现在似乎有必要思考X/A平衡的概念是如何限制了对果蝇性别决定信号的认识的。
