性别决定与剂量补偿：来自果蝇和线虫的经验教训。

Sex determination and dosage compensation: lessons from flies and worms.

作者信息

Parkhurst S M, Meneely P M

机构信息

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

出版信息

Science. 1994 May 13;264(5161):924-32. doi: 10.1126/science.8178152.

DOI:10.1126/science.8178152

PMID:8178152

Abstract

In both Drosophila melanogaster and Caenorhabditis elegans somatic sex determination, germline sex determination, and dosage compensation are controlled by means of a chromosomal signal known as the X:A ratio. A variety of mechanisms are used for establishing and implementing the chromosomal signal, and these do not appear to be similar in the two species. Instead, the study of sex determination and dosage compensation is providing more general lessons about different types of signaling pathways used to control alternative developmental states of cells and organisms.

摘要

在果蝇和秀丽隐杆线虫中，体细胞性别决定、生殖系性别决定以及剂量补偿均通过一种名为X:A比率的染色体信号来控制。建立和实施该染色体信号采用了多种机制，而这两种物种中的这些机制似乎并不相似。相反，性别决定和剂量补偿的研究正在为用于控制细胞和生物体不同发育状态的不同类型信号通路提供更普遍的经验教训。