Iatsyk P K, Botvin'eva V V, Sentsova T B, Tadzhibaev A T, Akhmedov Iu M, Zorkin S N, Madibraimov K M
Urol Nefrol (Mosk). 1993 Sep-Oct(5):13-5.
A total of 117 children with chronic pyelonephritis (CP) aged 4-14 were examined and treated. 57 of them having attendant cystitis received multimodality treatment comprising local intravesicular instillations of chigain controlled by clinical findings, urinalysis, cystoscopy and urinary secretory immunoglobulins SIg A1, SIg A2 and IgG. The drug chigain capable of immune replacement was found to initiate clinical response, positive trends in urinalysis and cystoscopy data, in the levels of secretory urine immunoglobulins. The findings show the need of immune replacement therapy in the complex of modalities to treat children with CP combined with cystitis.
对117名年龄在4至14岁的慢性肾盂肾炎（CP）患儿进行了检查和治疗。其中57名伴有膀胱炎的患儿接受了多模式治疗，包括根据临床症状、尿液分析、膀胱镜检查以及尿液分泌免疫球蛋白SIg A1、SIg A2和IgG进行局部膀胱内灌注奇卡林。发现具有免疫替代作用的奇卡林能引发临床反应，使尿液分析和膀胱镜检查数据以及分泌性尿液免疫球蛋白水平呈现积极趋势。研究结果表明，在治疗患有CP合并膀胱炎的儿童时，免疫替代疗法是综合治疗方案中所必需的。
