Becker L E, Zhang W, Pereyra P M
Department of Pathology (Neuropathology), University of Toronto, Ontario, Canada.
Acta Neuropathol. 1993;86(6):617-22. doi: 10.1007/BF00294301.
Abnormalities of the respiratory control system have been implicated in the cause of death in sudden infant death syndrome (SIDS). The vagus nerve is a major component of the neural regulation of respiration. Ultrastructural quantitative morphometry of myelinated and unmyelinated fibers was performed on cervical vagus nerves taken from 30 SIDS victims and 29 age-matched controls between 1 and 9 months of age. In SIDS infants, more small and fewer large myelinated vagal fibers were found than in controls, suggesting that the vagus nerve in SIDS is relatively immature. Delayed vagal nerve maturation, together with delays in central nervous system myelination and dendritic development, indicates a neural developmental delay in SIDS, the cause of which is undetermined.
呼吸控制系统异常与婴儿猝死综合征（SIDS）的死因有关。迷走神经是呼吸神经调节的主要组成部分。对30例1至9个月大的SIDS受害者和29例年龄匹配的对照者的颈迷走神经进行了有髓和无髓纤维的超微结构定量形态学分析。与对照组相比，SIDS婴儿中发现的有髓迷走神经小纤维更多，大纤维更少，这表明SIDS中的迷走神经相对不成熟。迷走神经成熟延迟，加上中枢神经系统髓鞘形成和树突发育延迟，表明SIDS存在神经发育延迟，其原因尚不确定。
