Bartram H P, Scheppach W, Gerlach S, Ruckdeschel G, Kelber E, Kasper H
Department of Medicine, University of Wuerzburg, Germany.
Am J Clin Nutr. 1994 Feb;59(2):428-32. doi: 10.1093/ajcn/59.2.428.
Diet-induced changes in the colonic microflora seem to play a role in colon carcinogenesis. In this study the effects of a yogurt (500 mL/d for 3 wk) enriched with Bifidobacterium longum and 5 g lactulose/L (A) on the fecal bacterial flora and various risk indexes for colon carcinogenesis were tested in 12 healthy volunteers and compared with a conventional yogurt (B). Increased excretion of bifidobacteria (P < 0.017) was found after consumption of both yogurts compared with the prestudy periods, whereas cultural counts of aerobes and anaerobes were not different. Breath-hydrogen exhalation was elevated and mouth-to-cecum transit time was accelerated in the period of yogurt A ingestion (P < 0.05) whereas no differences were found for oral-anal mean transit time, stool weight and pH, and fecal concentrations of short-chain fatty acids, bile acids, and neutral sterols. The results generally indicate great stability of the human fecal flora to this kind of dietary intervention.
饮食引起的结肠微生物群变化似乎在结肠癌发生过程中起作用。在本研究中，对12名健康志愿者测试了富含长双歧杆菌和5 g乳果糖/L的酸奶（每天500 mL，持续3周）（A）对粪便细菌菌群及结肠癌发生的各种风险指标的影响，并与传统酸奶（B）进行比较。与研究前相比，食用两种酸奶后双歧杆菌排泄均增加（P < 0.017），而需氧菌和厌氧菌的培养计数无差异。摄入酸奶A期间呼气氢排出增加，口至盲肠转运时间加快（P < 0.05），而口腔至肛门平均转运时间、粪便重量和pH值以及短链脂肪酸、胆汁酸和中性固醇的粪便浓度无差异。结果总体表明人类粪便菌群对这种饮食干预具有很大稳定性。
