系统性红斑狼疮中TAP2转运蛋白基因的多态性
Polymorphisms of the TAP2 transporter gene in systemic lupus erythematosus.
作者信息
Davies E J, Donn R P, Hillarby M C, Grennan D M, Ollier W E
机构信息
University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford.
出版信息
Ann Rheum Dis. 1994 Jan;53(1):61-3. doi: 10.1136/ard.53.1.61.
Abstract
OBJECTIVES
To determine whether the TAP2 transporter gene, which lies between HLA-DP and HLA-DQ, is involved in determining susceptibility to systemic lupus erythematosus (SLE).
METHODS
TAP2 types were determined by ARMS-PCR in 89 white patients with SLE and 156 control subjects.
RESULTS
No particular TAP2 dimorphism or allele was associated with SLE or with any clinical/immunological subgroup of SLE. Furthermore, there was no evidence for significant linkage disequilibrium between TAP2 and HLA-DQ/DR in SLE.
CONCLUSIONS
These data suggest that TAP2 is not a disease susceptibility gene for SLE and that the disease-predisposing haplotypes do not extend as far as TAP2. This indicates that any HLA-DP association with SLE must be independent of other class II (DQ/DR) associations.
摘要
目的
确定位于HLA - DP和HLA - DQ之间的TAP2转运蛋白基因是否参与系统性红斑狼疮（SLE）易感性的决定。
方法
采用扩增阻滞突变系统聚合酶链反应（ARMS - PCR）对89例白人SLE患者和156例对照者进行TAP2分型。
结果
未发现特定的TAP2二态性或等位基因与SLE或SLE的任何临床/免疫学亚组相关。此外，没有证据表明SLE中TAP2与HLA - DQ/DR之间存在显著的连锁不平衡。
结论
这些数据表明TAP2不是SLE的疾病易感基因，且疾病易感单倍型并不延伸至TAP2。这表明任何HLA - DP与SLE的关联必定独立于其他II类（DQ/DR）关联。
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本文引用的文献
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