Cardoso L F, Grinberg M, Ayres C V, Rati M A, Medeiros C C, Tarasoutchi F, Sant'Anna F M, Bellotti G
Instituto do Coração do Hospital das Clínicas-FMUSP, São Paulo.
Arq Bras Cardiol. 1993 May;60(5):301-5.
To evaluate percutaneous mitral balloon valvuloplasty (PMBV) in surgical high risk patients.
Twenty (12%) patients out of 172 submitted to a PMBV were considered high surgical risk cases; 17 (85%) were women and mean age was 43 (18-69). Thirteen (65%) were in acute pulmonary edema (3 were pregnant, 2 had previous cerebrovascular event, 1 had pulmonary thromboembolism and other had chronic renal failure), and 7 (35%) were in functional class (CF) III (2 had coronary artery disease, 2 severe obesity, 1 pulmonary neoplasia, 1 cardiac cachexia and one with previous cerebrovascular event). All patients underwent PMBV through transseptal technique. Double balloon was used in 10 (50%) patients; Inoue balloon in 5 (25%), mono-foil in 3 (15%) and bi-foil in 2 (10%).
Seventeen (85%) obtained success and 2 (10%) had clinical improvement. The hemodynamic results pre versus post-PMBV showed: left atrium pressure (LAP) mmHg 28.2 +/- 10.0 x 15.2 +/- 9.2 (n = 20) (p < 0.001), mitral medium gradient (G) mmHg 21.2 +/- 10.7 x 10.7 +/- 6.7 (n = 18) (p < 0.001), mitral valve area (MVA) cm2 0.73 +/- 0.3 x 1.73 +/- 0.6 (n = 11) (p < 0.001), pulmonary artery pressure mmHg 52.0 +/- 18.2 x 40.1 +/- 14.7 (n = 18) (p < 0.001) and cardiac index L/min/m2 2.1 +/- 0.4 x 2.5 +/- 0.6 (n = 14) (p < 0.001). Comparative echocardiography results pre, post and 6 months after PMBV showed: MVA 1.06 +/- 0.39 x 1.92 +/- 0.51 x 1.65 +/- 0.5 and G 13.8 +/- 4.7 x 7.3 +/- 3.6 x 7.3 +/- 4.4. There were two immediate deaths (pulmonary thromboembolism and multiple organs failure) and other after hospital discharge. The complications were: 2 (10%) patients with neurological complications, 1 (5%) atrial septal defect and other right atrium perforation (5%).
PMBV offers an alternative to surgical treatment in high risk surgical patients and the results are maintained in the 6 month follow-up.
评估经皮二尖瓣球囊成形术(PMBV)在外科手术高危患者中的应用。
172例行PMBV的患者中有20例(12%)被视为外科手术高危病例;17例(85%)为女性,平均年龄43岁(18 - 69岁)。13例(65%)处于急性肺水肿状态(3例为孕妇,2例曾有脑血管事件,1例有肺血栓栓塞,另1例有慢性肾衰竭),7例(35%)处于心功能分级(CF)III级(2例有冠状动脉疾病,2例严重肥胖,1例有肺肿瘤,1例有心脏恶病质,1例曾有脑血管事件)。所有患者均通过经房间隔技术行PMBV。10例(50%)患者使用双球囊;5例(25%)使用Inoue球囊,3例(15%)使用单叶球囊,2例(10%)使用双叶球囊。
17例(85%)手术成功,2例(10%)临床症状改善。PMBV术前与术后的血流动力学结果显示:左心房压力(LAP)mmHg 28.2±10.0变为15.2±9.2(n = 20)(p < 0.001),二尖瓣平均压差(G)mmHg 21.2±10.7变为10.7±6.7(n = 18)(p < 0.001),二尖瓣瓣口面积(MVA)cm² 0.73±0.3变为1.73±0.6(n = 11)(p < 0.001),肺动脉压力mmHg 52.0±18.2变为40.1±14.7(n = 18)(p < 0.001),心脏指数L/min/m² 2.1±0.4变为2.5±0.6(n = 14)(p < 0.001)。PMBV术前、术后及术后6个月的超声心动图对比结果显示:MVA分别为1.06±0.39、1.92±0.51、1.65±0.5,G分别为13.8±4.7、7.3±3.6、7.3±4.4。有2例即刻死亡(肺血栓栓塞和多器官功能衰竭),另1例在出院后死亡。并发症包括:2例(10%)患者有神经系统并发症,1例(5%)有房间隔缺损,另1例有右心房穿孔(5%)。
PMBV为外科手术高危患者提供了一种替代手术治疗的方法,并在6个月的随访中维持了治疗效果。