Albitskiĭ A V, Lakunin K Iu, Petukhov V A
Grud Serdechnososudistaia Khir. 1993 Nov-Dec(6):53-4.
Biochemical investigations carried out in patients with acute thrombophlebitis of the lower limb superficial veins showed that 70% of such patients develop marked changes in blood plasma lipid spectrum, hyperlipidemia. Blood serum lipid spectrum was examined in 19 patients with various forms of acute thrombophlebitis of the lower limb superficial veins and in 17 with varicose disease. Histologic material for morphologic examination (a fragment of the great subcutaneous vein near saphenofemoral anastomosis and of the wall near the thrombus) was collected during surgery. Venous wall fragments were examined under a light microscope for lipid content. The findings did not confirm the expected changes in venous wall in hyperlipidemia analogous with arterial wall changes in atherosclerosis. That is why we may propose that hyperlipidemia, though not directly changing venous wall structure, contributes to thrombogenesis process via other mechanisms.
对下肢浅静脉急性血栓性静脉炎患者进行的生化研究表明，70%的此类患者血浆脂质谱出现明显变化，即高脂血症。对19例各种形式的下肢浅静脉急性血栓性静脉炎患者和17例静脉曲张患者的血清脂质谱进行了检查。在手术过程中收集用于形态学检查的组织学材料（大隐静脉股隐静脉吻合口附近的皮下静脉片段和血栓附近的壁）。在光学显微镜下检查静脉壁碎片的脂质含量。研究结果未证实高脂血症时静脉壁会出现与动脉粥样硬化中动脉壁变化类似的预期变化。这就是为什么我们可以提出，高脂血症虽然不会直接改变静脉壁结构，但会通过其他机制促进血栓形成过程。
