Siimes M A, Ropponen P, Aalberg V, Komulainen J, Rautonen J
Children's Hospital, University of Helsinki, Finland.
J Adolesc Health. 1993 Nov;14(7):543-7. doi: 10.1016/1054-139x(93)90138-f.
A relationship appears to exist between prolactin metabolism and psychosexual development. We studied pubertal stage, testicular size, and serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, thyroxine, thyroid-stimulating hormone (TSH), and prolactin concentrations in 94 adolescent males who had survived malignancies in childhood. Of the patients, 22% had elevated serum prolactin, > 300 mU/L. In multivariate analysis, the only therapeutic agents or treatments found to be independently associated with prolactin concentration were cisplatin and cytosine arabinose. Administration of cisplatin was associated with an increase of 55 m U/L (p < 0.01) and that of cytosine arabinoside with an increase of 23 mU/L (p < 0.01) in serum prolactin concentration. Serum prolactin concentration correlated with serum FSH (r = 0.26, p = 0.16) and LH (r = 0.30, p = 0.005). In 45 of the patients 10 criteria of psychosexual development were evaluated using a personal, semi-structured, and psychodynamically-oriented interview. A significant inverse relation existed between serum prolactin concentration and dating with the opposite sex (p = 0.008); none of the patients with elevated serum prolactin were dating. We conclude that even a slight elevation of serum prolactin above normal is associated with or may be reflected in the psychosexual development of adolescent males who have survived malignancies in childhood.
催乳素代谢与性心理发育之间似乎存在某种关联。我们研究了94名童年期曾患恶性肿瘤且存活下来的青春期男性的青春期阶段、睾丸大小以及血清促卵泡激素（FSH）、促黄体生成素（LH）、睾酮、甲状腺素、促甲状腺激素（TSH）和催乳素浓度。这些患者中，22%的血清催乳素升高，>300 mU/L。在多变量分析中，发现唯一与催乳素浓度独立相关的治疗药物或治疗方法是顺铂和阿糖胞苷。使用顺铂与血清催乳素浓度升高55 mU/L相关（p<0.01），使用阿糖胞苷与血清催乳素浓度升高23 mU/L相关（p<0.01）。血清催乳素浓度与血清FSH（r = 0.26，p = 0.16）和LH（r = 0.30，p = 0.005）相关。在45名患者中，通过个人、半结构化且以心理动力学为导向的访谈评估了10项性心理发育标准。血清催乳素浓度与与异性约会之间存在显著的负相关（p = 0.008）；血清催乳素升高的患者均无正在约会的情况。我们得出结论，即使血清催乳素略高于正常水平也与童年期曾患恶性肿瘤且存活下来的青春期男性的性心理发育有关，或可能在其中有所体现。
