Reddingius R E, Schröder C H, Willems H L, van den Brandt F C, Koomen G C, Krediet R T, Monnens L A
Department of Paediatrics, Sint Radboud University Hospital, Nijmegen, The Netherlands.
Perit Dial Int. 1994;14(1):42-7.
Previous measurements of peritoneal fluid handling in children treated by continuous ambulatory peritoneal dialysis (CAPD) were performed with human albumin as a fluid marker. A major disadvantage of this substance is that endogenous patient albumin enters the peritoneal cavity during the dwell period. For this reason peritoneal fluid kinetics were measured in a group of children on CAPD, using autologous hemoglobin as a volume marker.
Autologous hemoglobin was added to dialysate containing 1.36% glucose as a volume marker. Marker clearance (MC), which is presently the best available approximation of lymphatic absorption in the clinical setting, and transcapillary ultrafiltration (TCUF) were measured during a 4-hour dwell.
University hospital.
Children on CAPD (N = 9), with a median age of 8.1 years (range 2.1-3.2 years).
MC was 521 +/- 166 mL/4 hour/1.73 m2, which is high compared to the literature data on adult CAPD patients. TCUF was 519 +/- 92 mL/4 hour/1.73 m2, which is similar to data concerning adult patients. TCUF reached no maximum during the 4-hour dwell, and the deviation of the TCUF curve from linear was markedly less than usually seen in adult patients.
MC in children treated with CAPD is higher when compared to the literature data on adults. Difficulties to achieve sufficient ultrafiltration in children could be caused by relatively small differences between MC and TCUF from the beginning to the end of the dwell.
以往对接受持续性非卧床腹膜透析（CAPD）治疗的儿童腹膜液处理情况的测量，是以人白蛋白作为液体标志物进行的。该物质的一个主要缺点是，内源性患者白蛋白在留存期会进入腹腔。因此，在一组接受CAPD治疗的儿童中，以自体血红蛋白作为容量标志物来测量腹膜液动力学。
将自体血红蛋白添加到含有1.36%葡萄糖的透析液中作为容量标志物。在4小时的留存期内测量标志物清除率（MC，目前在临床环境中可获得的对淋巴吸收的最佳近似值）和跨毛细血管超滤（TCUF）。
大学医院。
接受CAPD治疗的儿童（N = 9），中位年龄8.1岁（范围2.1 - 3.2岁）。
MC为521±166 mL/4小时/1.73 m²，与关于成人CAPD患者的文献数据相比偏高。TCUF为519±92 mL/4小时/1.73 m²，与成人患者的数据相似。在4小时的留存期内，TCUF未达到最大值，并且TCUF曲线与线性的偏差明显小于成人患者中通常所见。
与关于成人的文献数据相比，接受CAPD治疗的儿童的MC较高。从留存期开始到结束，MC和TCUF之间相对较小的差异可能导致儿童难以实现足够的超滤。
