Kumano K, Yokota S, Sakai T, Kazama H, Sofue K
Kidney Center, Kitasato University Hospital, Kanagawa, Japan.
Perit Dial Int. 1994;14(1):52-5.
To examine features of drainage flow and to determine whether the drainage period could be safely reduced in continuous ambulatory peritoneal dialysis (CAPD) patients.
Open nonrandomized prospective study in CAPD patients.
The kidney center in a tertiary care university hospital.
Fourteen CAPD patients with good catheter function.
Drainage flow pattern was studied using a 2-L dialysate. The drainage period was reduced from 28 minutes (mean) to 10 minutes throughout a short-term, 2-month study period and a long-term, 6-month study period for 10 patients.
Ultrafiltration volume, body weight, and peritoneal clearance.
A kinetics analysis of the drainage period and volume indicated a positive linear correlation with two different slopes: one for rapid drainage for the first 5-7 minutes and one for subsequent slow drainage. The effluent exceeded 80% in the former period. Ultrafiltration volume and body weight showed no change due to the reduction. Improved peritoneal clearance of small molecular substances could not be confirmed despite a 5% increase in the effective dialysis period. Nearly all patients were satisfied with the reduction and desired its continuation.
Ten minutes is a sufficient drainage period for most CAPD patients with a 2-L dialysate volume. This may possibly allow an increase in daily activities and an effective peritoneal membrane dialysate contact period.
研究持续性非卧床腹膜透析（CAPD）患者的引流特点，并确定是否可以安全缩短引流时间。
对CAPD患者进行开放性非随机前瞻性研究。
一所三级护理大学医院的肾脏中心。
14例导管功能良好的CAPD患者。
使用2L透析液研究引流模式。在为期2个月的短期研究期和为期6个月的长期研究期内，10例患者的引流时间从平均28分钟缩短至10分钟。
超滤量、体重和腹膜清除率。
引流时间和引流量的动力学分析表明，二者呈正线性相关，斜率不同：前5 - 7分钟快速引流，随后缓慢引流。前期流出量超过80%。超滤量和体重未因引流时间缩短而改变。尽管有效透析时间增加了5%，但小分子物质的腹膜清除率并未得到改善。几乎所有患者对引流时间缩短感到满意，并希望继续保持。
对于大多数使用2L透析液量的CAPD患者，10分钟的引流时间足够。这可能会增加日常活动，并延长腹膜与透析液的有效接触时间。
