[The effect of 3-mercaptopropionic acid on the toxicity of GABA-lytics for mice].
作者信息
Golovko A I, Sofronov G A, Kliuntina T V
出版信息
Biull Eksp Biol Med. 1993 Nov;116(11):526-7.
PMID:8312550
Abstract
The influence of 3-mercaptopropionic acid (3-MPA) on toxicities of bicuculline and picrotoxin was evaluated in mice. It was demonstrated that 3-MPA pretreatment for 5 min increased the toxicities of bicuculline and picrotoxin by 26% and 31%, respectively. 3-MPA did not alter the binding of (3H)TBOB and (3H)GABA to synaptosomal brain membranes of intact mice. The changes in toxicity may be associated with increased binding of GABA-antagonists to their receptors due to decreased brain GABA.
摘要
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