Golbs S, Fuchs V, Leipner E, Hüttel I
Arch Exp Veterinarmed. 1978;32(4):557-61.
The growing use of a diversity of pesticides in agricultural practice calls for studies into the toxicity of pesticides when used in combinations. Fundamental studies were conducted into the acute toxicity of pesticide combinations in rat and showed that double or triple combinations of parathion-methyl, carbaryl, and Lindan could aggravate or mitigate toxicity, depending on the active ingredients involved. The above findings were obtained from acute animal experiments, but it may well be necessary to develop proper screening models for optimum information and to study subchronic toxicity as well.
农业实践中越来越多地使用多种农药，这就需要对农药组合使用时的毒性进行研究。已对大鼠进行了农药组合急性毒性的基础研究，结果表明，甲基对硫磷、西维因和林丹的双重或三重组合的毒性可能会加剧或减轻，这取决于所涉及的活性成分。上述发现来自急性动物实验，但很可能有必要开发适当的筛选模型以获取最佳信息，同时也研究亚慢性毒性。
