Kurosky A, Markel D E, Peterson J W, Fitch W M
Science. 1977 Jan 21;195(4275):299-301. doi: 10.1126/science.831277.
The completed sequence of the beta-chain of cholera toxin (103 amino acid residues) was compared to the beta-chains of chorionic gonadotropin, thyrotropin, luteinizing, and follicle stimulating hormones. The overall chemical similarity of the toxin beta-chain to the hormones was not statistically different from random; however, a comparison of the first 40 residues of the toxin beta-chain to the glycoprotein hormones revealed a segment of the hormones which was significantly chemically similar. The probability was less than .003 that the similarity was due to chance.
将霍乱毒素β链（103个氨基酸残基）的完整序列与绒毛膜促性腺激素、促甲状腺激素、促黄体生成素和促卵泡激素的β链进行了比较。毒素β链与这些激素的总体化学相似性在统计学上与随机情况无异；然而，将毒素β链的前40个残基与糖蛋白激素进行比较时，发现这些激素中有一段在化学上具有显著的相似性。这种相似性由偶然因素导致的概率小于0.003。
