Bespalov V G, Aleksandrov V A, Lidak M Iu
Eksp Klin Farmakol. 1993 Sep-Oct;56(5):35-7.
Three models of cancerogenesis were used to test the anti-cancerogenic effects of pentoxiphylline. In female rats, breast adenocarcinoma was induced by intramammary injections of N-methyl-N-nitrosourea (MNU) or colonic and rectal adenocarcinomas by intrarectal instillations of MNU. In female mice, squamous cell carcinomas of the cervix uteri and vagina were induced by intravaginal applications of 7,12-dimethyl-benz(a) anthracene (DMBA). Pentoxifylline was given with drinking water at a concentration of 500 mg/l long at the stage of carcinogenesis promotion/progression. Pentoxifylline exerted a strong inhibitory effect on the development of mammary tumors and a moderate inhibitory effect on the development of colonic and rectal tumors induced by MNU in rats. However, the drug did not affect the development of cervical and vaginal tumors caused by DMBA in mice.
使用三种癌症发生模型来测试己酮可可碱的抗癌作用。在雌性大鼠中，通过乳腺内注射N-甲基-N-亚硝基脲（MNU）诱导乳腺腺癌，或通过直肠内滴注MNU诱导结肠和直肠腺癌。在雌性小鼠中，通过阴道内应用7,12-二甲基苯并(a)蒽（DMBA）诱导子宫颈和阴道鳞状细胞癌。在致癌促进/进展阶段，以500 mg/l的浓度将己酮可可碱加入饮用水中长时间给药。己酮可可碱对大鼠中由MNU诱导的乳腺肿瘤的发展具有强烈的抑制作用，对结肠和直肠肿瘤的发展具有中等抑制作用。然而，该药物不影响由DMBA引起的小鼠子宫颈和阴道肿瘤的发展。
