Bespalov V G, Davydov V V, Limarenko A Iu, Slepian L I, Aleksandrov V A
Biull Eksp Biol Med. 1993 Nov;116(11):534-6.
The anticarcinogenic effects of bioginseng and two germanium-selective drugs produced by cultivating cells of ginseng radix (Panax ginseng C. A. Mey) in a conventional medium or in media containing organogermanium compounds were studied. Squamous-cell carcinomas of the uterus cervix and vagina were induced by intravaginal applications of 7,12-dimethylbenz(a)anthracene in mice. The drugs of ginseng were used orally or intravaginally during a long period of time of the postinitiation stage of carcinogenesis. All the drugs used locally effectively inhibited the development of induced carcinomas of the uterus cervix and vagina. When orally used, the drugs of ginseng exhibited only an insignificant tendency to inhibit the carcinogenesis of uterus cervix and vagina. The anticarcinogenic effects of the compared drugs were similar.
研究了在常规培养基或含有机锗化合物的培养基中培养人参根（Panax ginseng C. A. Mey）细胞所产生的生物人参及两种锗选择性药物的抗癌作用。通过在小鼠阴道内应用7,12 - 二甲基苯并(a)蒽诱导子宫颈和阴道的鳞状细胞癌。在致癌作用起始后阶段的较长时间内，口服或经阴道使用人参药物。所有局部使用的药物均有效抑制了诱导的子宫颈和阴道癌的发展。口服时，人参药物仅表现出对子宫颈和阴道致癌作用的轻微抑制倾向。所比较药物的抗癌作用相似。
