Huang G W
Department of Nutrition and Food Hygiene, Tianjin Medical College.
Zhonghua Yi Xue Za Zhi. 1993 Oct;73(10):618-21, 639.
Rabbits were used to study the toxic effects of A1 on their skeleton. The A1 content in bone, serum A1 content and PTH level were increased along with A1 intake increase, and there was positive correlation between them (P < 0.01). Bone Ca and P contents were increased with A1 intake increase, but serum Ca level was decreased. Pathological examination of decalcified bone sections revealed no apparent changes between test and control groups. Histomorphometric results of undecalcified bone sections showed that osteoid of low and high A1 intake groups tended to increase, mineralization process of high A1 intake group was inhibited, and bone tissue formation of low A1 intake group tended to increase.
用兔子来研究铝对其骨骼的毒性作用。随着铝摄入量的增加，骨骼中的铝含量、血清铝含量和甲状旁腺激素水平均升高，且它们之间呈正相关（P<0.01）。随着铝摄入量的增加，骨钙和磷含量增加，但血清钙水平降低。脱钙骨切片的病理检查显示，试验组和对照组之间无明显变化。未脱钙骨切片的组织形态计量学结果表明，低铝和高铝摄入量组的类骨质有增加趋势，高铝摄入量组的矿化过程受到抑制，低铝摄入量组的骨组织形成有增加趋势。
