Zhen W J
Beijing Hospital.
Zhonghua Wai Ke Za Zhi. 1993 Jun;31(6):358-9.
Eighteen cases had successful heart surgery (correction of congenital cardiac deformity in 6, valve replacement in 7, and CABG in 5) with normothermic cardiopulmonary-bypass. The main characteristics of warm heart surgery include normothermic perfusion for keeping the body temperature in normal range, that is core temperature at 35-37 degrees C, and arresting the heart by continuous administration of warm oxygenated blood cardioplegia. The cardioplegia was composed of 1 portion of high-potassium crystalloid solution and 4 portions of oxygenated blood. The crystalloid solution was St. Thomas solution adding some Kcl to make the potassium concentration at 80 or 40mmol/L. In the 18 cases, 17 hearts returned beating from arresting spontaneously, but 2 hearts had resuscitation delayed because of hyperkalemia. There were no low output syndrome, serious cardiac arrhythmia and operative death. No myocardial ischemic and reperfusion periods were noted in warm heart surgery so ischemic/reperfusion injury could be almost eliminated. However there were too much blood in the operative field and hyperkalemia tendency.
18例患者在常温体外循环下成功进行了心脏手术(6例矫正先天性心脏畸形,7例进行瓣膜置换,5例进行冠状动脉搭桥术)。温心手术的主要特点包括常温灌注以保持体温在正常范围,即核心体温在35 - 37摄氏度,通过持续输注温氧合血心脏停搏液使心脏停跳。心脏停搏液由1份高钾晶体溶液和4份氧合血组成。晶体溶液为圣托马斯溶液,添加一些氯化钾使钾浓度达到80或40mmol/L。在这18例患者中,17例心脏在停跳后自发恢复跳动,但2例因高钾血症复苏延迟。无低心排血量综合征、严重心律失常及手术死亡。温心手术未观察到心肌缺血和再灌注期,因此缺血/再灌注损伤几乎可以消除。然而,手术野有过多血液且有高钾血症倾向。