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In vitro methods for assessing human hepatic drug metabolism: their use in drug development.

作者信息

Wrighton S A, Vandenbranden M, Stevens J C, Shipley L A, Ring B J, Rettie A E, Cashman J R

机构信息

Department of Drug Metabolism, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.

出版信息

Drug Metab Rev. 1993;25(4):453-84. doi: 10.3109/03602539308993982.

DOI:10.3109/03602539308993982
PMID:8313838
Abstract
摘要

相似文献

1
In vitro methods for assessing human hepatic drug metabolism: their use in drug development.
Drug Metab Rev. 1993;25(4):453-84. doi: 10.3109/03602539308993982.
2
Proceedings: Drug metabolism in the human liver measured with in vitro and in vivo methods.会议论文:采用体外和体内方法测定人体肝脏中的药物代谢
Arzneimittelforschung. 1976;26(6):1262-3.
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Interactions of drug metabolites with hepatic cytochrome P-450. Some implications for drug metabolism.药物代谢产物与肝细胞色素P-450的相互作用。对药物代谢的一些启示。
Pharm Weekbl Sci. 1982 Aug 20;4(4):113-4.
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[Study of hepatic drug metabolism. For a rationalization of a new molecular development].[肝脏药物代谢研究。旨在实现新分子研发的合理化]
Therapie. 1994 Mar-Apr;49(2):133-40.
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Factors regulating drug metabolism in intact hepatocytes.完整肝细胞中调节药物代谢的因素。
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Nuclear drug metabolism: its ontogeny in the rat and its presence in human fetal life.核药物代谢:其在大鼠中的个体发生及其在人类胎儿期的存在。
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Clinical implications of genetic polymorphisms and drug interactions mediated by cytochrome P-450 enzymes.细胞色素P-450酶介导的基因多态性和药物相互作用的临床意义。
Drug Metabol Drug Interact. 1997;14(2):55-82.
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Comparison of human and rhesus monkey in vitro phase I and phase II hepatic drug metabolism activities.
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Genetic factors in hepatic drug oxidation.肝脏药物氧化中的遗传因素。
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Effect of manganese on hepatic drug metabolism in male and female rats.锰对雄性和雌性大鼠肝脏药物代谢的影响。
Res Commun Chem Pathol Pharmacol. 1984 Feb;43(2):307-15.

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