Schleimer R P
Johns Hopkins Asthma and Allergy Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
Eur J Clin Pharmacol. 1993;45 Suppl 1:S3-7; discussion S43-4. doi: 10.1007/BF01844196.
Glucocorticoids (GC) exert a variety of important anti-inflammatory actions. We have studied their effects in allergic inflammation and believe that their anti-allergic effects reflect their anti-inflammatory activities in general. These effects include inhibition of cytokine and other mediator secretion, inhibition of leucocyte priming in eosinophils and neutrophils, reduction of vascular permeability, inhibition of arachidonic acid metabolite and platelet activating factor (PAF) release, synergistic or permissive effects on responses to other mediators, such as catecholamines and other endogenous hormone-like molecules, and modulation of enzyme systems involved in inflammation. Glucocorticoid actions are thus multifaceted; this feature explains both their unequalled efficacy in inflammatory diseases and the difficulty in replacing them with other medications that have a uni-dimensional profile of action.
糖皮质激素（GC）具有多种重要的抗炎作用。我们研究了它们在过敏性炎症中的作用，并认为它们的抗过敏作用总体上反映了其抗炎活性。这些作用包括抑制细胞因子和其他介质的分泌，抑制嗜酸性粒细胞和中性粒细胞中的白细胞激活，降低血管通透性，抑制花生四烯酸代谢产物和血小板活化因子（PAF）的释放，对其他介质（如儿茶酚胺和其他内源性激素样分子）的反应具有协同或允许作用，以及调节参与炎症的酶系统。糖皮质激素的作用因此是多方面的；这一特性既解释了它们在炎症性疾病中无与伦比的疗效，也解释了用其他具有单一作用模式的药物替代它们的困难。
