Goulding Nicolas J
William Harvey Research Institute, Barts and the London, Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.
Curr Opin Pharmacol. 2004 Dec;4(6):629-36. doi: 10.1016/j.coph.2004.06.009.
Glucocorticoids have been the mainstay of anti-inflammatory therapy for the past 50 years despite the significant risks associated with their long-term use. Recent research into the molecular mechanisms of action of these compounds can be aggregated into two major themes: first, those that focus on the involvement of the glucocorticoid receptor in regulating the transcription of pro-inflammatory genes; and second, studies that seek to identify alternative pathways of glucocorticoid action either via the induction of anti-inflammatory mediators or through rapid non-genomic mechanisms. Understanding the temporal-spatial patterns of these multiple mechanisms on relevant cell types will be key to explaining the profound effects that these four-ring steroids exert on the inflammatory process.
在过去的50年里，糖皮质激素一直是抗炎治疗的主要手段，尽管其长期使用存在重大风险。最近对这些化合物作用分子机制的研究可以归纳为两个主要主题：第一，关注糖皮质激素受体在调节促炎基因转录中的作用；第二，试图通过诱导抗炎介质或通过快速非基因组机制来确定糖皮质激素作用的替代途径。了解这些多种机制在相关细胞类型上的时空模式，将是解释这些四环类固醇对炎症过程产生深远影响的关键。
